|
KMID : 1151920200020010021
|
|
Chronobiology in Medicine
2020 Volume.2 No. 1 p.21 ~ p.24
|
|
|
Restless Legs Syndrome Caused by Quetiapine
|
|
Park Young-Min
|
|
|
Abstract
|
|
|
|
In addition to patients presenting with primary restless legs syndrome (RLS), clinicians may also encounter patients presenting with drug-induced RLS. Drug-induced RLS is a commonly observed adverse event in patients receiving atypical antipsychotics (AAP). The individual AAPs have been shown to induce RLS at varying frequencies. In particular, olanzapine and quetiapine have been reported to induce RLS at higher rate than do the other AAPs. Considering quetiapine’s low affinity for the dopamine receptor, AAP-induced RLS cannot be attributed to the degree of dopamine blockade alone. Observations from previous pharmacokinetic studies indicating that quetiapine exhibits transiently high D2 occupancy when initially administered could offer an explanation for this high rate of RLS induction. Several additional reports have indicated that the symptoms of RLS may be exacerbated by administration of anti-histaminic drugs, which is of interest in the context of quetiapine’s high affinity for the H1 receptor. Still, the exact mechanism by which AAPs induce RLS remains unclear. This article will review the current clinical evidence regarding quetiapine-induced RLS.
|
|
|
KEYWORD
|
|
|
Quetiapine, Restless legs syndrome, Atypical antipsychotics
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|